Resorcinol is thought to type covalent bonds with haem Sessler et al. Effects on the thyroid gland have been reported each in animal research and in case-stories in humans. However, there are species differences within the susceptibility to goitrogens.
There is no guideline study on toxicity for aquatic plants available. As only one concentration was tested, the research cannot be used in the risk analysis. There are a number of research obtainable on acute toxicity to totally different fish species.
No resorcinol-associated macroscopic findings, organ weight, or antagonistic microscopic target organ results have been noticed within the F 0 and F 1 parental animals. The F zero and F 1 females continued to receive the resorcinol throughout mating, gestation, and lactation and thru the day of euthanasia for research design, see Appendix 7. There had been no F zero and F 1 parental resorcinol-related deaths or clinical findings during the weekly detailed physical examinations. In controls and the excessive-dose group, a qualitative histopathological evaluation of the brain forebrain, midbrain, and hindbrain was also performed for the aforementioned animals RTF, There have been no antagonistic effects regarding reproductive performance, mortality, and physique or organ weights.
Two lengthy-term research with Swiss mice or NZW rabbits, where the animals had been treated with zero. In an in vitro. In an investigation in three human volunteers using conditions much like these utilized in hair dyeing, 14 C-ring-labelled 1. This means that solely a small amount of resorcinol penetrates the pores and skin through the actual strategy of hair colouring.
Although thyroid effects are a big end-point in both human case-studies and animal research, there is a lack of consistency in the ends in the animal research. Resorcinol triggered no antagonistic results in a number of copy and developmental toxicity studies in rats and rabbits. Resorcinol is not considered to be genotoxic.
The organisms had been uncovered to the test concentrations for 96 h. Biological observations were performed every day.
The third study, carried out in , included of energetic employees. In subjects men, thirteen girls with a mean age of 37 years, each laboratory and other tests, together with medical examination, were done; no abnormal thyroid glands or modifications in T four values had been present in any of the themes when compared with regular values Bauer, The above information are limited because of small research sizes, lack of comparison groups, lacking present and historic management information, and lacking info regarding potential exposure classes. In a research in a plant producing resorcinol by sulfonation of benzene — and also producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — staff have been exposed primarily to resorcinol, but the exposure to different brokers was not measured for publicity ranges, see part 6. In this plant, three cross-sectional research were carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary perform, haematology, and clinical chemistry have been carried out with of individuals actively employed at a manufacturing plant in Pennsylvania, USA. In addition, male rats have greater circulating ranges of TSH than females.